Below is a training-grade, GMP- and QbD-aligned module on Reporting Best Practices for SFE Analytical Data, designed for lab, pilot, and industrial settings, and suitable for regulators, buyers, auditors, and investors.

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Reporting Best Practices for SFE Analytical Data

(GC, HPLC, MS – Lab → Pilot → Industrial)

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1. Why Reporting Matters in SFE

In SFE, good data poorly reported = rejected product.

Reporting must support:

• Scientific reproducibility
• GMP batch release
• Buyer confidence (perfumery, pharma, nutraceutical)
• Scale-up decisions
• Legal and regulatory audits

If it isn’t documented, it didn’t happen.

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2. Core Principles of High-Quality Reporting

Principle	Meaning
Accuracy	True reflection of results
Completeness	No critical data omitted
Traceability	Sample → method → analyst
Consistency	Comparable across batches
Clarity	Readable by non-chemists

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3. Mandatory Report Sections

3.1 Sample Information

• Sample ID / batch number
• Source material (species, origin)
• Extraction method (SFE parameters)
• Fraction ID (if applicable)
• Date & analyst

📌 Never report results without traceable sample IDs

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3.2 Method Description

• Instrument type & model
• Column & detector
• Method reference (SOP code)
• Calibration model
• Internal standard (if used)

📌 Avoid “in-house method” without details

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3.3 Analytical Conditions

• GC oven program / HPLC gradient
• Flow rates
• Injection volume
• Ionization mode (MS)

📌 Required for reproducibility

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3.4 Results Presentation

Quantitative Results Table

Compound	Concentration	Unit	RSD	Method
Compound A	1.25	% w/w	3.2	GC-FID

✔ Use absolute units
🚫 Avoid area %

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3.5 Chromatograms & Spectra

• Clearly labeled peaks
• Retention times
• Scale visible
• Annotated target compounds

📌 One chromatogram = one sample or fraction

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4. Yield Reporting Best Practices

Always Specify:

• Dry weight basis
• Total extract yield (%)
• Target compound yield (%)
• Fraction-specific yields
• CO₂ usage (kg/kg)

Recommended Table

Fraction	Yield (%)	Target (%)	CO₂ Ratio

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5. Component Profiling Reporting

Best Practice

• Report marker compounds
• Report ratios, not just totals
• Use fingerprint overlays for QC

Example (Perfumery)

Compound	Batch A	Batch B	Spec

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6. Uncertainty & Variability Reporting

✔ Replicates (n ≥ 3)
✔ Mean ± SD
✔ RSD (%)

📌 Required for validation & scale-up

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7. Method Validation Summary

Include a concise validation table:

Parameter	Result	Acceptance
Linearity	R² = 0.998	≥ 0.995
Accuracy	97–103%	95–105%
Precision	RSD 2.8%	≤ 5%

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8. Compliance Statements

Include statements such as:

• “Method validated according to ICH Q2(R1)”
• “Residual solvents comply with ICH Q3C”
• “Analysis conducted under GMP-aligned SOPs”

📌 Language matters legally

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9. Common Reporting Errors

🚫 Area % without calibration
🚫 Missing sample IDs
🚫 No chromatograms
🚫 Undefined units
🚫 Mixing wet and dry basis
🚫 Overclaiming purity

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10. Audience-Specific Reporting

Regulators

• Validation data
• Full traceability

Buyers

• Marker compounds
• Consistency & purity

Investors

• Yield vs value
• Reproducibility metrics

Internal R&D

• Full raw data

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11. Data Integrity (ALCOA+)

✔ Attributable
✔ Legible
✔ Contemporaneous
✔ Original
✔ Accurate
✔ Complete
✔ Consistent

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12. Digital & File Management

• Raw data archived
• Version-controlled reports
• Secure backups
• Audit trail enabled

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13. Executive Summary (Best Practice)

Add a 1-page summary:

• Key findings
• Pass/fail vs specs
• Commercial relevance

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14. Key Takeaways

Good reporting turns chemistry into trust.

• Structure > volume
• Absolute values > percentages
• Profiles > yields
• Traceability > claims
• Compliance language > marketing language

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Next Steps I Can Deliver

• GMP-ready SFE analytical report template (PDF/Word)
• GC-MS / HPLC reporting SOP
• Buyer-friendly Certificate of Analysis (CoA)
• Agarwood-specific reporting standards
• Investor-grade technical summary

Tell me which one you want, and I’ll prepare it.